Output
(last update Feb 1st, 2023)
PhD theses
- BLACKMAN Marine. Director: Pierre Sonveaux (ongoing)
- BRUSTENGA Chiara. Director: Raphaël Frédérick, co-Director: Pierre Sonveaux (ongoing)
- COLAUZZI Ilaria. Director: Pierre Sonveaux (ongoing)
- s'HOSE Donatienne. Director: Bernard Gallez, co-Director: Bénédicte Jordan (PhD thesis obtained in 2022)
- MATHIEU Barbara. Director: Bernard Gallez, co-Director: Pierre Sonveaux (ongoing)
- RONDEAU Justin. Director: Pierre Sonveaux (ongoing)
- SAVOYEN Perrine. Director: Raphaël Frédérick, co-Director: Pierre Sonveaux (ongoing)
- VAN DE VELDE Justine. Director: Pierre Sonveaux (ongoing)
- ZAMPIERI Luca. Director: Pierre Sonveaux (PhD thesis obtained in 2022)
Peer-reviewed publications (those acknowledging ARC are marked with a *)
2021 (from 01/10)
Lesari S, Leclercq I, Joudiou N, Komuta M, Daumerie A, Ambroise J, Dili A, Feza-Bingi N, Xhema D, Bouzin C, Gallez B, Pisani F, Bonaccorsi-Riani E, Gianello P. Selective HIF stabilization alleviates hepatocellular steatosis and ballooning in a rodent model of 70% liver resection. Clin Sci (Lond). 2021;135:2285-2305.
*Zampieri LX, Sboarina M, Cacace A, Grasso D, Thabault L, Hamalin L, Vazeille T, Dumon E, Rossignol R, Frédérick R, Sonveaux E, Lefranc F, Sonveaux P. Olaparib is a mitochondrial Complex I inhibitor that kills temozolomide-resistant human glioblastoma cells. Int. J. Mol. Sci. 2021;22:11938.
Cappellesso F, Orban MP, Shirgaonkar N, Berardi E, Serneels J, Neveu MA, Di Molfetta D, Piccapane F, Caroppo R, Debellis L, Ostyn T, Joudiou N, Mignion L, Richiardone E, Jordan BF, Gallez B, Corbet C, Roskams T, DasGupta R, Tejpar S, Di Matteo M, Taverna D, Reshkin SJ, Topal B, Virga F, Mazzone M. Targeting the bicarbonate transporter SLC4A4 overcomes immunosuppression and immunotherapy resistance in pancreatic cancer. Nat Cancer. 2022;3:1464-1483.
Vander Veken L, Dechambre D, Sterpin E, Souris K, Van Ooteghem G, Aldo Lee J, Geets X. Incorporation of tumor motion directionality in margin recipe: the directional MidP strategy. Phys Med. 2021;91:43-53.
2022
*Thabault L, Brustenga C, Savoyen P, Van Gysel M, Wouters J, Sonveaux P, Frederick R, Liberelle M. Discovery of small molecules interacting at lactate dehydrogenases tetrameric interface using a biophysical screening cascade. Eur. J. Med. Chem. 2022;230:114102.
*Ippolito L, Sonveaux P, Chiarugi P. Lactate: unconventional roles of a nutrient along the tumor landscape. Trends Endocrinol. Metabol. 2022;33(4):231-235.
Kemps H, Dessy C, Dumas L, Sonveaux P, Alders L, Van Broeckhoven J, Perez Font L, Lambrichts S, Foulquier S, Hendrix S, Brone B, Lemmens R, Bronckaers A. Extremely low frequency electromagnetic stimulation reduces ischemic stroke volume by improving central collateral blood flow. J. Cereb. Blood Flow Metab. 2022;42:979-996.
*Capeloa T, Krzystyniak J, d’Hose D, Canas Rodriguez A, Payen VL, Zampieri LX, Van de Velde J, Benyahia Z, Pranzini E, Vazeille T, Fransolet M, Bouzin C, Brusa D, Michiels C, Gallez B, Murphy MP, Porporato PE, Sonveaux P. MitoQ inhibits human breast cancer cell migration, invasion and clonogenicity. Cancers 2022;14:1516.
*Capeloa T, Krzystyniak J, Canas Rodriguez A, Payen VL, Zampieri LX, Pranzini E, Derouane F, Vazeille T, Bouzin C, Duhoux FP, Murphy MP, Porporato PE, Sonveaux P. MitoQ prevents human breast cancer recurrence and lung metastasis in mice. Cancers 2022;14:1488.
Macchi C, Moregola A, Greco MF, Svecla M, Bonacina F, Dhup S, Dadhich RK, Audano M, Sonveaux P, Mauro C, Mitro N, Ruscica M, Norata GD. Monocarboxylate transporter 1 deficiency impacts CD8 + T lymphocytes proliferation and recruitment to adipose tissue during obesity. iScience 2022;25(6):104435.
Weber DD, Aminzadeh-Gohari S, Thapa M, Redtenbacher AS, Catalano L, Capeloa T, Vazeille T, Emberger M, Felder TK, Feichtinger RG, Koelblinger P, Dallmann G, Sonveaux P, Lang R, Kofler B. Ketogenic diets slow melanoma growth in vivo regardless of tumor genetics and metabolic plasticity. Cancer Metab. 2022;10(1):12.
Blackman MCN, Capeloa T, Rondeau JD, Zampieri LX, Benyahia Z, Van de Velde J, Fransolet M, Daskalopoulos EP, Michiels C, Beauloye C, Sonveaux P. Mitochondrial protein Cox7b is a metabolic sensor driving brain-specific metastasis of human breast cancer cells. Cancers 2022;14:4371.
*D’Hose D, Mathieu B, Mignion L, Hardy M, Ouari O, Jordan BF, Sonveaux P, Gallez B. EPR Investigations to study the impact of mito-metformin on the mitochondrial function of prostate cancer cells. Molecules 2022;27(18):5872.
*D’Hose Donatienne, Mignion Lionel, Hamelin L, Sonveaux P, Jordan BF, Gallez B. Statins alleviate tumor hypoxia in prostate cancer models by decreasing oxygen consumption: an opportunity for radiosensitization? Biomolecules 2022;12(10):1418.
*Capeloa T, Van de Velde J, d’Hose D, Lipari SG, Derouane F, Hamelin L, Bedin M, Vazeille T, Duhoux FP, Murphy MP, Porporato PE, Gallez B, Sonveaux P. Inhibition of mitochondrial redox signaling with mitoQ prevents metastasis of human pancreatic cancer in mice. Cancers 2022;14(19):4918.
*Farah C, Neveu MA, Yelek C, Bouzin C, Gallez B, Baurain JF, Mignion L, Jordan BF. Combined HP 13C pyruvate and 13C-glucose fluxomic as a potential marker of response to targeted therapies in YUMM1.7 melanoma xenografts. Biomedicines 2022;10:717.
Gossuin Y, Gallez B. Editorial for "Phase I Randomized Trial of 17 O-Labeled Water: Safety and Feasibility Study of Indirect Proton MRI for the Evaluation of Cerebral Water Dynamics": old concepts, new applications. J Magn Reson Imaging. 2022;56:1883-1884.
Buyse C, Joudiou N, Warscotte A, Richiardone E, Minion L, Corbet C, Gallez B. Evaluation of syrosingopine, an MCT inhibitor, as potential modulator of tumor metabolism and extracellular acidification. Metabolites 2022 Jun 17;12(6):557.
d'Hose D, Gallez B. Measurement of mitochondrial (dys)function in cellular systems using electron Paramagnetic Resonance (EPR): Oxygen Consumption Rate and Superoxide Production. Methods Mol Biol 2022;2497:83-95.
Gallez B. The role of imaging biomarkers to guide pharmacological interventions targeting tumor hypoxia. Front Pharmacol. 2022;13:853568.
Saade G, Bogaerts E, Chiavassa S, Blain G, Delpon G, Evin M, Ghannam Y, Haddad F, Haustermans K, Koumeir C, Macaeva E, Maigne L, Mouchard Q, Servagent N, Sterpin E, Supiot S, Potiron V. Ultrahigh-dose-rate proton irradiation elicits reduced toxicity in zebrafish embryos. Adv Radiat Oncol. 2022;8:101124.
*Terwagne M, Nicolas E, Hespeels B, Herter L, Virgo J, Demazy C, Heuskin AC, Hallet B, Van Doninck K. DNA repair during nonreductional meiosis in the asexual rotifer Adineta vaga. Sci Adv. 2022;8:eadc8829.
Borderías-Villarroel E, Taasti V, Van Elmpt W, Teruel-Rivas S, Geets X, Sterpin E. Evaluation of the clinical value of automatic online dose restoration for adaptive proton therapy of head and neck cancer. Radiother Oncol. 2022;170:190-197.
Barragán-Montero A, Bibal A, Dastarac MH, Draguet C, Valdés G, Nguyen D, Willems S, Vandewinckele L, Holmström M, Löfman F, Souris K, Sterpin E, Lee JA. Towards a safe and efficient clinical implementation of machine learning in radiation oncology by exploring model interpretability, explainability and data-model dependency. Phys Med Biol. 2022;67:11TR01.
van der Heyden B, Heymans SV, Carlier B, Collado-Lara G, Sterpin E, D'hooge J. Deep learning for dose assessment in radiotherapy by the super-localization of vaporized nanodroplets in high frame rate ultrasound imaging. Phys Med Biol. 2022;67:115015.
Toumia Y, Pullia M, Domenici F, Facoetti A, Ferrarini M, Heymans SV, Carlier B, Van Den Abeele K, Sterpin E, D'hooge J, D'Agostino E, Paradossi G. Ultrasound-assisted carbon ion dosimetry and range measurement using injectable polymer-shelled phase-change nanodroplets: in vitro study. Sci Rep. 2022;12:8012.
Wuyckens S, Saint-Guillain M, Janssens G, Zhao L, Li X, Ding X, Sterpin E, Lee JA, Souris K. Treatment planning in arc proton therapy: Comparison of several optimization problem statements and their corresponding solvers. Comput Biol Med. 2022;148:105609.
Elhamiasl M, Salvo K, Poels K, Defraene G, Lambrecht M, Geets X, Sterpin E, Nuyts J. Low-dose CT allows for accurate proton therapy dose calculation and plan optimization. Phys Med Biol. 2022;67:195015.
Draguet C, Barragán-Montero AM, Vera MC, Thomas M, Populaire P, Defraene G, Haustermans K, Lee JA, Sterpin E. Automated clinical decision support system with deep learning dose prediction and NTCP models to evaluate treatment complications in patients with esophageal cancer. Radiother Oncol. 2022;176:101-107.
Wuyckens S, Zhao L, Saint-Guillain M, Janssens G, Sterpin E, Souris K, Ding X, Lee JA. Bi-criteria Pareto optimization to balance irradiation time and dosimetric objectives in proton arc therapy. Phys Med Biol. 2022;67(24):245017.
2023
Buti G, Shusharina N, Ajdari A, Sterpin E, Bortfeld T. Exploring trade-offs in treatment planning for brain tumor cases with a probabilistic definition of the clinical target volume. Med Phys. 2023;50:410-423.
Ternad I, Penninckx S, Lecomte V, Vangijzegem T, Conrard L, Lucas S, Heuskin AC, Michiels C, Muller RN, Stanicki D, Laurent S. Advances in the mechanistic understanding of iron oxide nanoparticles' radiosensitizing properties. Nanomaterials (Basel). 2023;13:201.
Patents applications: 2
PhD theses
- BLACKMAN Marine. Director: Pierre Sonveaux (ongoing)
- BRUSTENGA Chiara. Director: Raphaël Frédérick, co-Director: Pierre Sonveaux (ongoing)
- COLAUZZI Ilaria. Director: Pierre Sonveaux (ongoing)
- s'HOSE Donatienne. Director: Bernard Gallez, co-Director: Bénédicte Jordan (PhD thesis obtained in 2022)
- MATHIEU Barbara. Director: Bernard Gallez, co-Director: Pierre Sonveaux (ongoing)
- RONDEAU Justin. Director: Pierre Sonveaux (ongoing)
- SAVOYEN Perrine. Director: Raphaël Frédérick, co-Director: Pierre Sonveaux (ongoing)
- VAN DE VELDE Justine. Director: Pierre Sonveaux (ongoing)
- ZAMPIERI Luca. Director: Pierre Sonveaux (PhD thesis obtained in 2022)
Peer-reviewed publications (those acknowledging ARC are marked with a *)
2021 (from 01/10)
Lesari S, Leclercq I, Joudiou N, Komuta M, Daumerie A, Ambroise J, Dili A, Feza-Bingi N, Xhema D, Bouzin C, Gallez B, Pisani F, Bonaccorsi-Riani E, Gianello P. Selective HIF stabilization alleviates hepatocellular steatosis and ballooning in a rodent model of 70% liver resection. Clin Sci (Lond). 2021;135:2285-2305.
*Zampieri LX, Sboarina M, Cacace A, Grasso D, Thabault L, Hamalin L, Vazeille T, Dumon E, Rossignol R, Frédérick R, Sonveaux E, Lefranc F, Sonveaux P. Olaparib is a mitochondrial Complex I inhibitor that kills temozolomide-resistant human glioblastoma cells. Int. J. Mol. Sci. 2021;22:11938.
Cappellesso F, Orban MP, Shirgaonkar N, Berardi E, Serneels J, Neveu MA, Di Molfetta D, Piccapane F, Caroppo R, Debellis L, Ostyn T, Joudiou N, Mignion L, Richiardone E, Jordan BF, Gallez B, Corbet C, Roskams T, DasGupta R, Tejpar S, Di Matteo M, Taverna D, Reshkin SJ, Topal B, Virga F, Mazzone M. Targeting the bicarbonate transporter SLC4A4 overcomes immunosuppression and immunotherapy resistance in pancreatic cancer. Nat Cancer. 2022;3:1464-1483.
Vander Veken L, Dechambre D, Sterpin E, Souris K, Van Ooteghem G, Aldo Lee J, Geets X. Incorporation of tumor motion directionality in margin recipe: the directional MidP strategy. Phys Med. 2021;91:43-53.
2022
*Thabault L, Brustenga C, Savoyen P, Van Gysel M, Wouters J, Sonveaux P, Frederick R, Liberelle M. Discovery of small molecules interacting at lactate dehydrogenases tetrameric interface using a biophysical screening cascade. Eur. J. Med. Chem. 2022;230:114102.
*Ippolito L, Sonveaux P, Chiarugi P. Lactate: unconventional roles of a nutrient along the tumor landscape. Trends Endocrinol. Metabol. 2022;33(4):231-235.
Kemps H, Dessy C, Dumas L, Sonveaux P, Alders L, Van Broeckhoven J, Perez Font L, Lambrichts S, Foulquier S, Hendrix S, Brone B, Lemmens R, Bronckaers A. Extremely low frequency electromagnetic stimulation reduces ischemic stroke volume by improving central collateral blood flow. J. Cereb. Blood Flow Metab. 2022;42:979-996.
*Capeloa T, Krzystyniak J, d’Hose D, Canas Rodriguez A, Payen VL, Zampieri LX, Van de Velde J, Benyahia Z, Pranzini E, Vazeille T, Fransolet M, Bouzin C, Brusa D, Michiels C, Gallez B, Murphy MP, Porporato PE, Sonveaux P. MitoQ inhibits human breast cancer cell migration, invasion and clonogenicity. Cancers 2022;14:1516.
*Capeloa T, Krzystyniak J, Canas Rodriguez A, Payen VL, Zampieri LX, Pranzini E, Derouane F, Vazeille T, Bouzin C, Duhoux FP, Murphy MP, Porporato PE, Sonveaux P. MitoQ prevents human breast cancer recurrence and lung metastasis in mice. Cancers 2022;14:1488.
Macchi C, Moregola A, Greco MF, Svecla M, Bonacina F, Dhup S, Dadhich RK, Audano M, Sonveaux P, Mauro C, Mitro N, Ruscica M, Norata GD. Monocarboxylate transporter 1 deficiency impacts CD8 + T lymphocytes proliferation and recruitment to adipose tissue during obesity. iScience 2022;25(6):104435.
Weber DD, Aminzadeh-Gohari S, Thapa M, Redtenbacher AS, Catalano L, Capeloa T, Vazeille T, Emberger M, Felder TK, Feichtinger RG, Koelblinger P, Dallmann G, Sonveaux P, Lang R, Kofler B. Ketogenic diets slow melanoma growth in vivo regardless of tumor genetics and metabolic plasticity. Cancer Metab. 2022;10(1):12.
Blackman MCN, Capeloa T, Rondeau JD, Zampieri LX, Benyahia Z, Van de Velde J, Fransolet M, Daskalopoulos EP, Michiels C, Beauloye C, Sonveaux P. Mitochondrial protein Cox7b is a metabolic sensor driving brain-specific metastasis of human breast cancer cells. Cancers 2022;14:4371.
*D’Hose D, Mathieu B, Mignion L, Hardy M, Ouari O, Jordan BF, Sonveaux P, Gallez B. EPR Investigations to study the impact of mito-metformin on the mitochondrial function of prostate cancer cells. Molecules 2022;27(18):5872.
*D’Hose Donatienne, Mignion Lionel, Hamelin L, Sonveaux P, Jordan BF, Gallez B. Statins alleviate tumor hypoxia in prostate cancer models by decreasing oxygen consumption: an opportunity for radiosensitization? Biomolecules 2022;12(10):1418.
*Capeloa T, Van de Velde J, d’Hose D, Lipari SG, Derouane F, Hamelin L, Bedin M, Vazeille T, Duhoux FP, Murphy MP, Porporato PE, Gallez B, Sonveaux P. Inhibition of mitochondrial redox signaling with mitoQ prevents metastasis of human pancreatic cancer in mice. Cancers 2022;14(19):4918.
*Farah C, Neveu MA, Yelek C, Bouzin C, Gallez B, Baurain JF, Mignion L, Jordan BF. Combined HP 13C pyruvate and 13C-glucose fluxomic as a potential marker of response to targeted therapies in YUMM1.7 melanoma xenografts. Biomedicines 2022;10:717.
Gossuin Y, Gallez B. Editorial for "Phase I Randomized Trial of 17 O-Labeled Water: Safety and Feasibility Study of Indirect Proton MRI for the Evaluation of Cerebral Water Dynamics": old concepts, new applications. J Magn Reson Imaging. 2022;56:1883-1884.
Buyse C, Joudiou N, Warscotte A, Richiardone E, Minion L, Corbet C, Gallez B. Evaluation of syrosingopine, an MCT inhibitor, as potential modulator of tumor metabolism and extracellular acidification. Metabolites 2022 Jun 17;12(6):557.
d'Hose D, Gallez B. Measurement of mitochondrial (dys)function in cellular systems using electron Paramagnetic Resonance (EPR): Oxygen Consumption Rate and Superoxide Production. Methods Mol Biol 2022;2497:83-95.
Gallez B. The role of imaging biomarkers to guide pharmacological interventions targeting tumor hypoxia. Front Pharmacol. 2022;13:853568.
Saade G, Bogaerts E, Chiavassa S, Blain G, Delpon G, Evin M, Ghannam Y, Haddad F, Haustermans K, Koumeir C, Macaeva E, Maigne L, Mouchard Q, Servagent N, Sterpin E, Supiot S, Potiron V. Ultrahigh-dose-rate proton irradiation elicits reduced toxicity in zebrafish embryos. Adv Radiat Oncol. 2022;8:101124.
*Terwagne M, Nicolas E, Hespeels B, Herter L, Virgo J, Demazy C, Heuskin AC, Hallet B, Van Doninck K. DNA repair during nonreductional meiosis in the asexual rotifer Adineta vaga. Sci Adv. 2022;8:eadc8829.
Borderías-Villarroel E, Taasti V, Van Elmpt W, Teruel-Rivas S, Geets X, Sterpin E. Evaluation of the clinical value of automatic online dose restoration for adaptive proton therapy of head and neck cancer. Radiother Oncol. 2022;170:190-197.
Barragán-Montero A, Bibal A, Dastarac MH, Draguet C, Valdés G, Nguyen D, Willems S, Vandewinckele L, Holmström M, Löfman F, Souris K, Sterpin E, Lee JA. Towards a safe and efficient clinical implementation of machine learning in radiation oncology by exploring model interpretability, explainability and data-model dependency. Phys Med Biol. 2022;67:11TR01.
van der Heyden B, Heymans SV, Carlier B, Collado-Lara G, Sterpin E, D'hooge J. Deep learning for dose assessment in radiotherapy by the super-localization of vaporized nanodroplets in high frame rate ultrasound imaging. Phys Med Biol. 2022;67:115015.
Toumia Y, Pullia M, Domenici F, Facoetti A, Ferrarini M, Heymans SV, Carlier B, Van Den Abeele K, Sterpin E, D'hooge J, D'Agostino E, Paradossi G. Ultrasound-assisted carbon ion dosimetry and range measurement using injectable polymer-shelled phase-change nanodroplets: in vitro study. Sci Rep. 2022;12:8012.
Wuyckens S, Saint-Guillain M, Janssens G, Zhao L, Li X, Ding X, Sterpin E, Lee JA, Souris K. Treatment planning in arc proton therapy: Comparison of several optimization problem statements and their corresponding solvers. Comput Biol Med. 2022;148:105609.
Elhamiasl M, Salvo K, Poels K, Defraene G, Lambrecht M, Geets X, Sterpin E, Nuyts J. Low-dose CT allows for accurate proton therapy dose calculation and plan optimization. Phys Med Biol. 2022;67:195015.
Draguet C, Barragán-Montero AM, Vera MC, Thomas M, Populaire P, Defraene G, Haustermans K, Lee JA, Sterpin E. Automated clinical decision support system with deep learning dose prediction and NTCP models to evaluate treatment complications in patients with esophageal cancer. Radiother Oncol. 2022;176:101-107.
Wuyckens S, Zhao L, Saint-Guillain M, Janssens G, Sterpin E, Souris K, Ding X, Lee JA. Bi-criteria Pareto optimization to balance irradiation time and dosimetric objectives in proton arc therapy. Phys Med Biol. 2022;67(24):245017.
2023
Buti G, Shusharina N, Ajdari A, Sterpin E, Bortfeld T. Exploring trade-offs in treatment planning for brain tumor cases with a probabilistic definition of the clinical target volume. Med Phys. 2023;50:410-423.
Ternad I, Penninckx S, Lecomte V, Vangijzegem T, Conrard L, Lucas S, Heuskin AC, Michiels C, Muller RN, Stanicki D, Laurent S. Advances in the mechanistic understanding of iron oxide nanoparticles' radiosensitizing properties. Nanomaterials (Basel). 2023;13:201.
Patents applications: 2